Acknowledgement of receipt of copies of an entered book
…alities, namely, Malan syndrome (MAL) and Marshall–Smith syndrome (MSS). NFIX mutations associated with MAL mainly cluster in exon 2 and are cleared by nonsense-mediated decay (NMD) leading to NFIX haploinsufficiency, whereas NFIX mutations associated with MSS are clustered in exons 6–10 and escape NMD and result in the production of dominant-negative mutant NFIX proteins. Thus, different NFIX mutations have distinct consequences on NFIX expression. To elucidate the in vivo effects of MSS-associated NFIX exon 7 mutations, we used CRISPR-Cas9 to generate mouse models with exon 7 deletions that comprised: a frameshift deletion of two nucleotides (Nfix Del2); in-frame deletion of 24 nucleotides (Nfix Del24); and deletion of 140 nucleotides (Nfix Del140). Nfix+/Del2, Nfix+/Del24, Nfix+/Del140, NfixDel24/Del24, and NfixDel140/Del140 mice were viable, normal, and fertile, with no skeletal abnormalities, but NfixDel2/Del2 mice had significantly reduced viability (p < 0.002) and died at 2–3 weeks of age. Nfix Del2 w…
Walking through a field of dried, brittle rapeseed somewhere near Lytchett Matravers, on the way to Sturminster Marshall, during Walk 2012
The Significance of Easter in Christian Theology A discussion of the significance of Easter and its implications for creation in Christian Theology.
The paper reports on theoretical research building on the work of Steadman, Marshall and others that examines in detail the basis for correlating the outputs of configurational analysis and urban tissue analysis. The aim of the research is to raise the yield of analysis when combining configurational and typo-morphological methods. A broader, overarching aim is to establish a bridge between the two different approaches to urban morphology that facilitates communication and helps to develop a more comprehensive and coherent set of concepts for understanding the structure and dynamics of the built environment.
Correspondence regarding the whereabouts of one of the judges's fee cheque, 7 Jun-29 Aug 1972
A flash video discussion of the Christian theology of Easter as a historical and continuing event in the Christian community.