Women are under-represented in academic grades in Higher Education, but more so in science, engineering and technology (SET) disciplines. This under-representation of women undermines the potential gains the community of science can attain by utilising the skills, talents and knowledge of all those who are trained to work in SET. The European Union statistics show that women are equally represented at undergraduate stage but become progressively more under-represented in the more senior academic positions. This article presents a case study of a mentoring programme in the Centre for Women in Science and Engineering Research (WiSER) at Trinity College Dublin. Its aim is the recruiting, retaining, returning and advancing women in academic science, engineering and technology. WiSER seeks to develop sustainable practices to ensure that women can compete in research in an equitable manner with male colleagues using their scientific expertise, knowledge and potential. The outcomes of the programme are reported for mentors, mentees and Trinity College and retention data are given for the women a year after the programme ended.