Book Chapter


The Anaphase Promoting Complex/Cyclosome (APC/C): A versatile E3 ubiquitin ligase

Abstract

In the present chapter we discuss the essential roles of the human E3 ubiquitin ligase Anaphase Promoting Complex/Cyclosome (APC/C) in mitosis as well as the emerging evidence of important APC/C roles in cellular processes beyond cell division control such as regulation of genomic integrity and cell differentiation of the nervous system. We consider the potential incipient role of APC/C dysregulation in the pathophysiology of the neurological disorder Alzheimer’s disease (AD). We also discuss how certain Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) viruses take control of the host’s cell division regulatory system through harnessing APC/C ubiquitin ligase activity and hypothesise the plausible molecular mechanisms underpinning virus manipulation of the APC/C. We also examine how defects in the function of this multisubunit protein assembly drive abnormal cell proliferation and lastly argue the potential of APC/C as a promising therapeutic target for the development of innovative therapies for the treatment of chronic malignancies such as cancer.

Attached files

Authors

Curtis, Natalie L.
Bolaños-Garcia Victor M.

Oxford Brookes departments

Department of Biological and Medical Sciences

Dates

Year of publication: 2020
Date of RADAR deposit: 2020-09-08



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Related resources

This RADAR resource is the Accepted Manuscript of The Anaphase Promoting Complex/Cyclosome (APC/C): A versatile E3 ubiquitin ligase
This RADAR resource is Part of Macromolecular protein complexes II: Structure and function [ISBN: 9783030281502] / edited by J. Robin Harris and Jon Marles-Wright.

Details

  • Owner: Joseph Ripp
  • Collection: Outputs
  • Version: 1 (show all)
  • Status: Live