Journal Article

Gene3D: Extensive prediction of globular domains in proteins

Abstract

Gene3D (http://gene3d.biochem.ucl.ac.uk) is a database of globular domain annotations for millions of available protein sequences. Gene3D has previously featured in the Database issue of NAR and here we report a significant update to the Gene3D database. The current release, Gene3D v16, has significantly expanded its domain coverage over the previous version and now contains over 95 million domain assignments. We also report a new method for dealing with complex domain architectures that exist in Gene3D, arising from discontinuous domains. Amongst other updates, we have added visualization tools for exploring domain annotations in the context of other sequence features and in gene families. We also provide web-pages to visualize other domain families that co-occur with a given query domain family.

Attached files

Authors

Lewis, Tony E.
Sillitoe, Ian
Dawson, Natalie
Lam, Su Datt
Clarke, Tristan
Lee, David
Orengo, Christine
Lees, Jonathan

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2017
Date of RADAR deposit: 2018-02-08

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This work is licensed under a Creative Commons Attribution 4.0 International License

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Related resources

This RADAR resource is the Version of Record of Gene3D: Extensive prediction of globular domains in proteins