Ehlers-Danlos Syndromes (EDS) are a genetically heterogeneous, frequently under diagnosed, group of heritable connective tissue disorders (HCTD). Primary manifestations include joint hypermobility, muscle weakness, frailty and hyperextensibility of tissues, including the skin, ligaments and blood vessels [1], [2]. Current diagnosis is assessed via the Beighton Scale and Brighton Criteria; however, the Beighton Scale gives no indication of the precise degree of joint laxity [1], [3]. Additionally, the Brighton Criteria are accepted for the diagnosis of JHS/EDS-HT in adults, but not in children and young people. Neither criteria mention the predominance of hypermobility in females and the frequent presence of dysautonomic symptoms, gastrointestinal involvement and psychological manifestations [6].
Clinging, Hannah
Supervisors: Castleton, S
Faculty of Health and Life Sciences
Year: 2016
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