Journal Article


Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017: Meeting report

Abstract

This report summarises the presentations and activities of the ISEV Workshop on extracellular vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was broad agreement about the importance of biospecimen science. Much greater attention needs to be paid towards the provenance of collected samples. The workshop also highlighted clear gaps in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future utility of certified standards for credentialing of instruments and software, to analyse EV and for tracking the influence of isolation steps on the structure and content of EVs were also discussed. Several example studies were presented, demonstrating the potential utility for EVs in disease diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of the workshop was that more effort focused on pre-analytical issues and benchmarking of isolation methods is needed to strengthen collaborations and advance more effective biomarkers.

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Authors

Clayton, Aled
Buschmann, Dominik
Byrd, J. Brian
Carter, David R.F.
Chenge, Lesley
Compton, Carolyn
Daaboul, George
Devitt, Andrew
Falcon-Perez, Juan Manuel
Gardiner, Chris
Gustafson, Dakota
Harrison, Paul
Helmbrecht, Clemens
Hendrix, An
Hill, Andrew
Hoffman, Andrew
Jones, Jennifer C.
Kalluri, Raghu
Kang, Ji Yoon
Kirchner, Benedikt
Lässert, Cecilia
Lawson, Charlotte
Lenassi, Metka
Levin, Carina
Llorente, Alicia
Martens-Uzunova, Elena S.
Möller, Andreas
Musante, Luca
Ochiya, Takahiro
Pink, Ryan C.
Tahara, Hidetoshi
Wauben, Marca H.M.
Webber, Jason P.
Welsh, Joshua A.
Witwer, Kenneth W.
Yin, Hang
Nieuwland, Rienk

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2018
Date of RADAR deposit: 2018-09-04


Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License


Related resources

This RADAR resource is the Version of Record of Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017: Meeting report
This RADAR resource is the Version of Record of Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017: Meeting report

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  • Owner: Joseph Ripp
  • Collection: Outputs
  • Version: 1 (show all)
  • Status: Live