This report summarises the presentations and activities of the ISEV Workshop on extracellular
vesicle biomarkers held in Birmingham, UK during December 2017. Among the key messages was
broad agreement about the importance of biospecimen science. Much greater attention needs to
be paid towards the provenance of collected samples. The workshop also highlighted clear gaps
in our knowledge about pre-analytical factors that alter extracellular vesicles (EVs). The future
utility of certified standards for credentialing of instruments and software, to analyse EV and for
tracking the influence of isolation steps on the structure and content of EVs were also discussed.
Several example studies were presented, demonstrating the potential utility for EVs in disease
diagnosis, prognosis, longitudinal serial testing and stratification of patients. The conclusion of
the workshop was that more effort focused on pre-analytical issues and benchmarking of
isolation methods is needed to strengthen collaborations and advance more effective biomarkers.
Clayton, AledBuschmann, DominikByrd, J. BrianCarter, David R.F.Chenge, LesleyCompton, CarolynDaaboul, GeorgeDevitt, AndrewFalcon-Perez, Juan ManuelGardiner, ChrisGustafson, DakotaHarrison, PaulHelmbrecht, ClemensHendrix, AnHill, AndrewHoffman, AndrewJones, Jennifer C.Kalluri, RaghuKang, Ji YoonKirchner, BenediktLässert, CeciliaLawson, CharlotteLenassi, MetkaLevin, CarinaLlorente, AliciaMartens-Uzunova, Elena S.Möller, AndreasMusante, LucaOchiya, TakahiroPink, Ryan C.
Tahara, HidetoshiWauben, Marca H.M.Webber, Jason P.Welsh, Joshua A.Witwer, Kenneth W.Yin, HangNieuwland, Rienk
Faculty of Health and Life Sciences\Department of Biological and Medical Sciences
Year of publication: 2018Date of RADAR deposit: 2018-09-04
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