Journal Article


Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution

Abstract

Convergent phenotypic evolution is often caused by recurrent changes at particular nodes in the underlying gene regulatory networks (GRNs). The genes at such evolutionary ‘hotspots’ are thought to maximally affect the phenotype with minimal pleiotropic consequences. This has led to the suggestion that if a GRN is understood in sufficient detail, the path of evolution may be predictable. The repeated evolutionary loss of larval trichomes among Drosophila species is caused by the loss of shavenbaby (svb) expression. svb is also required for development of leg trichomes, but the evolutionary gain of trichomes in the ‘naked valley’ on T2 femurs in Drosophila melanogaster is caused by the loss of microRNA-92a (miR-92a) expression rather than changes in svb. We compared the expression and function of components between the larval and leg trichome GRNs to investigate why the genetic basis of trichome pattern evolution differs in these developmental contexts. We found key differences between the two networks in both the genes employed, and in the regulation and function of common genes. These differences in the GRNs reveal why mutations in svb are unlikely to contribute to leg trichome evolution and how instead miR-92a represents the key evolutionary switch in this context. Our work shows that variability in GRNs across different developmental contexts, as well as whether a morphological feature is lost versus gained, influence the nodes at which a GRN evolves to cause morphological change. Therefore, our findings have important implications for understanding the pathways and predictability of evolution.

Attached files

Authors

Kittelmann, Sebastian
Buffry, Alexandra D.
Franke, Franziska A.
Almudi, Isabel
Yoth, Marianne
Sabaris, Gonzalo
Couso, Juan Pablo
Nunes, Maria D.S.
Frankel, Nicolás
Gómez-Skarmeta, José Luis
Pueyo-Marques, Jose
Arif, Saad
McGregor, Alistair P.

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2018
Date of RADAR deposit: 2018-05-10


Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License


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  • Owner: Joseph Ripp
  • Collection: Outputs
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