Journal Article

Genomics, cys-loop ligand-gated ion channels and new targets for the control of insect pests and vectors

Abstract

Cys-loop ligand-gated ion channels (cysLGICs) play roles in the nervous system. They consist of five subunits arranged around a central ion channel with each subunit being encoded for by a separate gene. In insects, the cysLGIC superfamily commonly consists of 21-25 genes giving rise to several receptor classes such as nicotinic acetylcholine receptors and GABA receptors. Insect cysLGICs are of interest as they are the target of insecticides. Analyses of genome sequences have identified cysLGIC gene superfamilies from different species including crop pests, disease vectors and beneficial insects. This review explores recent studies that have pushed forward our knowledge about this superfamily and considers the potential of developing improved strategies to control insect pests whilst sparing non-target organisms.

Attached files

Authors

Jones, Andrew K.

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2018
Date of RADAR deposit: 2018-07-31

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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

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Related resources

This RADAR resource is the Accepted Manuscript of Genomics, cys-loop ligand-gated ion channels and new targets for the control of insect pests and vectors