Journal Article


Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation

Abstract

Case studies of unusual traits can provide unique snapshots of the effects of modified systems. In this study, we report on an individual from a Serbian family with the ability to rapidly, accurately and voluntarily speak backwards. We consider psychological, neural and genetic correlates of this trait to identify specific relevant neural mechanisms and new molecular pathways for working memory and speech-related tasks. EEG data suggest that the effect of word reversal precedes semantic integration of visually presented backward-words, and that event-related potentials above the frontal lobe are affected by both word reversal and the maintenance of backward-words in working memory. fMRI revealed that the left fusiform gyrus may facilitate the production of backward-speech. Exome sequencing identified three novel coding variants of potential significance in the RIC3, RIPK1 and ZBED5 genes. Taken together, our data suggest that, in this individual, the ability to speak backwards is afforded by an extraordinary working memory capacity. We hypothesise that this is served by cholinergic projections from the basal forebrain to the frontal cortex and supported by visual semantic loops within the left fusiform gyrus and that these neural processes may be mediated by a genetic mutation in RIC3; a chaperone for nicotinic acetylcholine receptors.

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Authors

Prekovic, S
?ur?evi?, D
Csifcsák, G
Šveljo, O
Stojkovi?, O
Jankovi?, M
Koprivšek, K
Covill, L
Lu?i?, M
Van der BroeCk, T
Helsen, C
Ceroni, F
Claessens, F
Newbury, D

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2016
Date of RADAR deposit: 2016-06-30


Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License


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This RADAR resource is the Version of Record of Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation
This RADAR resource is the Version of Record of Multidisciplinary investigation links backward-speech trait and working memory through genetic mutation

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