Book Chapter


Variations in the insect GABA receptor, RDL, and their impact on receptor pharmacology

Abstract

The resistance to dieldrin (RDL) receptor is an insect γ-aminobutyric acid (GABA) receptor, characterized by the dieldrin resistance mutation that was pivotal to understanding target based insecticide resistance. RDL is the target for various non-competitive antagonists, including dieldrin and fipronil, as well as novel acting compounds such as the meta-diamides and isoxazolines. Therefore the RDL receptor has returned to center stage as a relevant and effective insecticide target. Our understanding of the function of RDL in vivo is still unfolding, with the discovery of species specific post-transcriptional modifications such as alternative splicing and RNA editing, modifications shown to influence the pharmacology of the receptor. Exposing these receptors to insecticides also evokes ever evolving mechanisms of mutagenesis, and a number of contributory mutations have been identified both in field and laboratory resistant insects, occurring in parallel to the dieldrin resistance mutation. We present an overview of these variations and discuss the impact on the pharmacology of GABA and various insecticides.

Attached files

Authors

Taylor-Wells, Jennina
Jones, Andrew Ken

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2017
Date of RADAR deposit: 2017-10-26



https://creativecommons.org/licenses/by-nc-nd/4.0/ - This document is the Accepted Manuscript version of a Published Work that appeared in final form in Advances in agrochemicals: ion channels and G Protein-Coupled receptors (GPCRs) as Targets for Pest Control. Volume 2, GPCRs and Ion Channels (ACS Symposium Series), copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/bk-2017-1265.ch001


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