Journal Article


Discovery of 42 genome-wide significant loci associated with dyslexia

Abstract

Reading and writing are crucial life skills but roughly 1 in 10 children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Our genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls identified 42 independent significant loci: 15 in genes linked to cognitive ability/educational attainment; 27 novel and potentially more specific to dyslexia. Twenty-three loci (13 novel) were validated in independent cohorts of Chinese and European ancestry. Genetic aetiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.

Attached files

Authors

Doust, Catherine
Fontanillas, Pierre
Eising, Else
Gordon, Scott D.
Wang Zhengjun
Alagöz, Gökberk
Molz, Barbara
23andMe Research Team
Quantitative Trait Working Group of the GenLang Consortium
St Pourcain, Beate
Francks, Clyde
Marioni, Riccardo E.
Zhao Jingjing
Paracchini, Silvia
Talcott, Joel B.
Monaco, Anthony P.
Stein, John F.
Gruen, Jeffrey R.
Olson, Richard K.
Willcutt, Erik G.
DeFries, John C.
Pennington, Bruce F.
Smith, Shelley D.
Wright, Margaret J.
Martin, Nicholas G.
Auton, Adam
Bates, Timothy C.
Fisher, Simon E.
Luciano, Michelle

Oxford Brookes departments

Department of Biological and Medical Sciences

Dates

Year of publication: 2022
Date of RADAR deposit: 2022-04-11


Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License


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