Journal Article


Improved reference genome of Aedes aegypti informs arbovirus vector control

Abstract

Female Aedes aegypti mosquitoes infect more than 400 million people each year with dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in understanding the biology of mosquitoes and developing the tools to fight them has been slowed by the lack of a high-quality genome assembly. Here we combine diverse technologies to produce the markedly improved, fully re-annotated AaegL5 genome assembly, and demonstrate how it accelerates mosquito science. We anchored physical and cytogenetic maps, doubled the number of known chemosensory ionotropic receptors that guide mosquitoes to human hosts and egg-laying sites, provided further insight into the size and composition of the sex-determining M locus, and revealed copy-number variation among glutathione S-transferase genes that are important for insecticide resistance. Using high-resolution quantitative trait locus and population genomic analyses, we mapped new candidates for dengue vector competence and insecticide resistance. AaegL5 will catalyse new biological insights and intervention strategies to fight this deadly disease vector.

Attached files

Authors

Matthews, Benjamin J.
Dudchenko, Olga
Kingan, Sarah B.
Koren, Sergey
Antoshechkin, Igor
Crawford, Jacob E.
Glassford, William J.
Herre, Margaret
Redmond, Seth N.
Rose, Noah H.
Weedall, Gareth D.
Wu, Yang
Batra, Sanjit S.
Brito-Sierra, Carlos A.
Buckingham, Steven D.
Campbell, Corey L.
Chan, Saki
Cox, Eric
Evans, Benjamin R.
Fansiri, Thanyalak
Filipovi?, Igor
Fontaine, Albin
Gloria-Soria, Andrea
Hall, Richard
Joardar, Vinita S.
Jones, Andrew K.
Kay, Raissa G.G.
Kodali, Vamsi K.
Lee, Joyce
Lycett, Gareth J.
Mitchell, Sara N.
Muehling, Jill
Murphy, Michael R.
Omer, Arina D.
Partridge, Frederick A.
Peluso, Paul
Aiden, Aviva Presser
Ramasamy, Vidya
Raši?, Gordana
Roy, Sourav
Saavedra-Rodriguez, Karla
Sharan, Shruti
Sharma, Atashi
Smith, Melissa Laird
Turner, Joe
Weakley, Allison M.
Zhao, Zhilei
Akbari, Omar S.
Black IV, William C.
Cao, Han
Darby, Alistair C.
Hill, Catherine A.
Johnston, J. Spencer
Murphy, Terence D.
Raikhel, Alexander S.
Sattelle, David B.
Sharakhov, Igor V.
White, Bradley J.
Zhao, Li
Aiden, Erez Lieberman
Mann, Richard S.
Lambrechts, Louis
Powell, Jeffrey R.
Sharakhova, Maria V.
Tu, Zhijian
Robertson, Hugh M.
McBride, Carolyn S.
Hastie, Alex R.
Korlach, Jonas
Neafsey, Daniel E.
Phillippy, Adam M.
Vosshall, Leslie B.

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2018
Date of RADAR deposit: 2018-10-08


Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License


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