This integrative review of the literature synthesizes findings of previous research studies about the impact of Motivational Interviewing (MI) as an intervention to positive behavior change in adolescents who engage in risky behavior, and appraises current information about the possibility of Motivational Interviewing-via-Co-Active Life Coaching (MI-via-CALC) as an intervention to enhance self-efficacy and motivation in at-risk youth. Additionally, implications for practice and further research in relation to the impact of MI and MI-via-CACL as interventions to positive behavior change in adolescents are addressed.