Journal Article

A systematic review of the barriers and facilitators impacting patient enrolment in clinical trials for lung cancer


Purpose. Clinical research trials are needed to enhance the medical care and treatment for lung cancer, which remains the leading cause of cancer-related deaths worldwide. While clinical trials allow for the development of novel therapies to treat cancer, the recruitment of lung cancer patients to trials is low. This review aimed to identify and synthesise the available literature concerning barriers and facilitators affecting lung cancer patients’ decisions to enrol in clinical trials to guide future cancer research efforts. Methods. Four databases were systematically searched: Academic Search Complete, CINHAL, PubMed, and PsycINFO in August 2023. A supplemental grey literature search was also conducted alongside this. Articles were quality appraised using CASP and JMI checklists, and results were narratively synthesised. Results. Eighteen articles of varied design met the inclusion criteria, and results were mapped onto the Capability, Opportunity, and Motivation Behaviour (COM-B) Model to help structure and conceptualise review findings. Evidence suggests that the decision to enrol in a trial is multifaceted and informed by: when and how study information is presented, travel and trial eligibility, and altruistic hopes and fears. Conclusions. There is need to address the many different concerns that lung cancer patients have about participating in a clinical trial through the supply of accessible and timely trial information, and via the reduction of travel, expansion of study eligibility criteria, and recognition of a person's altruistic wishes, hopes, fears, and family-oriented concerns. Future research should aim to work alongside lung cancer patients, clinicians, and other stakeholders to increase research accessibility.

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Benjamin Lond a, Christopher Dodd a, Zoe Davey a, Liz Darlison b, John McPhelim c, Janette Rawlinson d e, Iain Williamson f, Clair Merriman a g, Francesca Waddington g, Dominic Bagnallainslie g, Balaji Rajendran g, Jesse Usman g, Catherine Henshall a g

Oxford Brookes departments

Oxford School of Nursing and Midwifery


Year of publication: 2024
Date of RADAR deposit: 2024-03-25

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License

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