The aim of this study was to assess the compatibility between characteristics of employees ‘at risk’ for sickness absence and components of a preventive coaching intervention. Data from baseline questionnaires of the ‘at risk’ study population of a randomized trial, and of two reference groups of the Maastricht Cohort Study were used to compare (mental) health and work related characteristics. Details of the intervention were described. Similarities between characteristics of the study population and components of the coaching intervention were discussed. Substantial differences between characteristics of the ‘at risk’ study population and the ‘not at risk’ reference group were found, which were all addressed during the coaching intervention. The contrast with the ‘sick leave’ reference group was less obvious. The ‘at risk’ study population could be indicated as the most beneficial population for this preventive intervention. The results show that preventive coaching is an appropriate intervention for employees ‘at risk’ for sickness absence.