Journal Article

A genome-scale model of Clostridium autoethanogenum reveals optimal bioprocess conditions for high-value chemical production from carbon monoxide

Abstract

Clostridium autoethanogenum is an industrial microbe used for the commercial-scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desirable, particularly in the formation of the high-value platform chemicals, such as 2,3-butanediol. A new, experimentally parameterised genome scale model of C. autoethanogenum predicts dramatically increased 2,3-butanediol production under non-carbon-limited conditions when thermodynamic constraints on hydrogen production are considered.

Attached files

Authors

Norman, Rupert
Millat, Thomas
Schatschneider, Sarah
Henstra, Anne
Breitkopf, Ronja
Pander, Bart
Annan, Florence
Piatek, Pawel
Hartman, Hassan
Poolman, Mark
Fell, David
Winzer, Klaus
Minton, Nigel
Hodgman, Charlie

Oxford Brookes departments

Faculty of Health and Life Sciences\Department of Biological and Medical Sciences

Dates

Year of publication: 2019
Date of RADAR deposit: 2019-04-18

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https://creativecommons.org/licenses/by/3.0/

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