Journal Article


The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein

Abstract

Slow lorises are enigmatic animal that represent the only venomous primate lineage. Their defensive secretions have received little attention. In this study we determined the full length sequence of the protein secreted by their unique brachial glands. The full length sequences displayed homology to the main allergenic protein present in cat dander. We thus compared the molecular features of the slow loris brachial gland protein and the cat dander allergen protein, showing remarkable similarities between them. Thus we postulate that allergenic proteins play a role in the slow loris defensive arsenal. These results shed light on these neglected, novel animals.

Attached files

Authors

Scheib, Holger
Nekaris, K.A.I.
Rode-Margono, Johanna
Ragnarsson, Lotten
Baumann, Kate
Dobson, James S.
Wirdateti Wirdateti
Nouwens, Amanda
Nijman, Vincent
Martelli, Paolo
Ma, Rui
Lewis, Richard J.
Kwok, Hang Fai
Fry, Bryan G.

Oxford Brookes departments

Department of Social Sciences

Dates

Year of publication: 2020
Date of RADAR deposit: 2021-01-07


Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License


Related resources

This RADAR resource is Identical to The toxicological intersection between allergen and toxin: a structural comparison of the cat dander allergenic protein Fel d1 and the slow loris brachial gland secretion protein.

Details

  • Owner: Joseph Ripp
  • Collection: Outputs
  • Version: 1 (show all)
  • Status: Live
  • Views (since Sept 2022): 256