This is an icon for use in RADAR to show that the full text of a file is not available on RADAR. It is used in the Research collection.
This is an icon for use in RADAR to show that the full text of a file is embargoed on RADAR. It is used in the Research collection.
This is an icon for use in RADAR to show that the full text of a file is available on RADAR. It is used in the Research collection.
This is an icon for use in RADAR to show a link to a publisher's website. It is used in the Research collection.
The unprecedented success of Italian crime drama serial Gomorrah – The Series has spurred much interest in the industry as well as a lively critical debate. Little attention, however, has thus far been paid to the creative process behind the series. This article contributes to filling this gap by investigating the branding strategies and the writing strategies that have informed the development process. Particular emphasis is given to the analysis of the storylining techniques employed in the development of the arcs of Season 1 with a view to unpacking how, in turn, these determine mechanisms of the viewers’ engagement with characters. As typical of much contemporary serial dramas, these are predominantly antiheroes and therefore our allegiance to them is questioned when problematic issues are raised, as in the case of violent actions and dubious moral choices. The investigation combines three interplaying methodologies – i.e. a genetic approach, close textual (quantitative and qualitative) analysis and a co…
Rice straw is a major crop residue which is burnt in many countries, creating signicant air pollution. Thus, alternative routes for disposal of rice straw are needed. Biotechnological treatment of rice straw hydrolysate has potential to convert this agriculture waste into valuable biofuel(s) and platform chemicals. Geobacillus thermoglucosidasius is a thermophile with properties specially suited for use as a biocatalyst in lignocellulosic bioprocesses, such as high optimal temperature and tolerance to high levels of ethanol. However, the capabilities of Geobacillus thermoglucosidasius to utilize sugars in rice straw hydrolysate for making bioethanol and other platform chemicals have not been fully explored. In this work, we have created a genome scale metabolic model (denoted iGT736) of the organism containing 736 gene products, 1159 reactions and 1163 metabolites. The model was validated both by purely theoretical approaches and by comparing the behaviour of the model to previously published experimental res…
Background: The baobab fruit is high in both dietary fibre and polyphenols and therefore may increase satiety. The aim of the study was to measure the effects of baobab fruit extract on satiety.
Methods: The study was conducted on 20 healthy participants. The study was a one day single blind crossover design. Participants were randomised to either a test smoothie consisting of 15g of baobab extract or a control smoothie without the addition of baobab. Subjective ratings of satiety were taken on visual analogue scales immediately pre consumption and then post consumption, and energy intake at a post ad libitum meal was recorded.
Results: Subjective measures of hunger were reduced following the test smoothie compared to the control (p<0.05). There was no significant difference in calorie intake at an ad libitum meal.
Conclusions: This research has positive implications for the use of baobab for reducing hunger, possibly having a positive effect on weight maintenance.
Large general population surveys show that heavy regular and episodic alcohol consumption are associated with lower intakes of fruits and vegetables, and higher intakes of processed and fried meat. This is of particular concern regarding pregnant women, as both alcohol intake and inadequate maternal nutrition are independently associated with adverse fetal outcomes. The current study aimed to determine associations between maternal dietary patterns and alcohol consumption during pregnancy.
Secondary analysis of data from the Avon Longitudinal Study of Parents and Children (ALSPAC). Women provided details of alcohol consumption at 18 weeks’ gestation and diet at 32 weeks’ gestation (n=9,839. Dietary patterns were derived from the food frequency questionnaire data using principal components analysis. Associations between alcohol consumption and dietary patterns were determined using multiple linear regression, adjusted for various socio-demographic and lifestyle factors.
A significant proportion of children have unexplained problems acquiring proficient linguistic skills despite adequate intelligence and opportunity. Developmental language disorders are highly heritable with substantial societal impact. Molecular studies have begun to identify candidate loci, but much of the underlying genetic architecture remains undetermined. We performed whole-exome sequencing of 43 unrelated probands affected by severe specific language impairment, followed by independent validations with Sanger sequencing, and analyses of segregation patterns in parents and siblings, to shed new light on aetiology. By first focusing on a pre-defined set of known candidates from the literature, we identified potentially pathogenic variants in genes already implicated in diverse language-related syndromes, including ERC1, GRIN2A, and SRPX2. Complementary analyses suggested novel putative candidates carrying validated variants which were predicted to have functional effects, such as OXR1, SCN9A and KMT2D. W…